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Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.
Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 522 | 5日内发货 |
产品描述 | Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. |
体内活性 | Lanoconazole (p.o.; 3, 10, or 30 mg/kg; once a day; 3 weeks) significantly inhibits?C. neoformans?compared with the saline control in normal mice. It obviously decreases the growth of?C. neoformans?in the lungs and brains of MAIDS mice. Lanoconazole (treatment for the ear; 0.3%-3%; 6 days) dose‐dependently inhibitsTPA-induced irritant dermatitis, inhibits the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2 and inhibited neutrophil infiltration to the inflammation site[2] [3]. |
分子量 | 319.83 |
分子式 | C14H10ClN3S2 |
CAS No. | 101530-10-3 |
密度 | 1.43 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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