受体酪氨酸激酶 (Receptor Tyrosine Kinases)

HER2 ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.

MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK Mer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.38 kDa and the accession number is Q60805.

EphA2 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 60 kDa and the accession number is NP_034269.2.

ROR1 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 42.8 kDa and the accession number is Q01973.

HER2 ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.

c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.

EphA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P29317.

HER2 ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.

TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.

AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.

HER3 ERBB3 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.5 kDa and the accession number is A6KSF8.

ACVR2B Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa.

HER3 ERBB3 Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.92 kDa and the accession number is XP_001113953.2.

TrkA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.95 kDa and the accession number is XP_005541454.3.

HER2 ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.

HER3 ERBB3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.

TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.

ErbB4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q99P91.

PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.

FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the accession number is A0A0R4IZY3.

AXL Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q00993.

HER2 ERBB2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.3 kDa and the accession number is XP_001090430.1.

PDGFRB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is Q05030.

EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754.

TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8.

FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.

c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.9 kDa and the accession number is P10721-1.

Mer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62 kDa and the accession number is Q12866.

ROR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69 kDa and the accession number is Q01973.

FGFR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.5 kDa and the accession number is AAA39377.1.

EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 59.4 kDa and the accession number is A0A024QZA8.

ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.2 kDa and the accession number is Q01973.

c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 58.50 kDa and the accession number is P10721-2.

HER3 ERBB3 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.4 kDa and the accession number is P21860-1.

PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2.

EphA4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.4kDa and the accession number is A0A8J8XFI3.

TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.

EphA4 Protein, Human, Recombinant (aa 570-986, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is P54764.

c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P10721-2.

HER3 ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.

TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.

HGFR c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.

Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is P16234.

FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the accession number is P21803-2.

FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.

FGFR4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.

Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER AXL TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganization. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE)， deficiency in MERTK are the cause of retinitis pigmentosa.

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR c-Met Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.5 kDa (α chain) and 69.9 kDa (β chain) and the accession number is A0A2K5UM36.