Name: Suzetrigine
Brand: TargetMol
SKU: T69552
Price: 329 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 329

现货

5 mg

¥ 787

现货

10 mg

¥ 1,170

现货

25 mg

¥ 1,880

现货

50 mg

¥ 3,270

现货

100 mg

¥ 4,680

现货

200 mg

¥ 6,530

现货

1 mL x 10 mM (in DMSO)

¥ 819

现货

产品介绍

生物活性

产品描述	Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.
靶点活性	NaV1.8:0.7 nM, NaV1.8 (rabbit):52 nM, NaV1.8 (dog):740 nM, Nav1.8 (human):0.68 ± 0.16 nM, NaV1.8 (monkey):0.75 nM, NaV1.8 (rat):56 nM, NaV1.8 (mouse):210 nM
体内活性	与安慰剂相比，Suzetrigine在最高剂量（起始口服剂量为Suzetrigine的100 mg，随后每12小时维持剂量50 mg），而非较低剂量（起始剂量为20 mg，随后每12小时维持剂量10 mg）时，能够在腹部整形手术或足拇囊切除术后的48小时内减轻急性痛感。[1]
别名	VX-548

化学信息

分子量	473.39
分子式	C₂₁H₂₀F₅N₃O₄
CAS No.	2649467-58-1
Smiles	C(NC=1C=C(C(N)=O)N=CC1)(=O)[C@H]2[C@@H]([C@H](C)[C@@]([C@@](F)(F)F)(C)O2)C3=C(OC)C(F)=C(F)C=C3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 161 mg/mL (340.1 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1124 mL	10.5621 mL	21.1242 mL	105.6212 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1242 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5621 mL
20 mM	0.1056 mL	0.5281 mL	1.0562 mL	5.2811 mL
50 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0562 mL

体内实验配液计算器