Muscimol hydrochloride is the salt form of Muscimol, the main psychoactive component of Amanita muscaria, a potent and selective GABAA receptor agonist and partial GABAC receptor agonist, with no activity on GABAB receptors. It is commonly used in central neuroscience research, with analgesic, anxiolytic and neuroprotective effects, with the advantage of being able to cross the blood-brain barrier and can be taken orally.

方法：在单独的实验中，豚鼠在静脉注射乙酰胆碱诱导的 Ppi 增加的控制值建立前 10 分钟，用选择性 GABAA 拮抗剂 gabazine (3.75 mg/kg,静脉注射) 进行预处理；在随后的静脉注射乙酰胆碱前 1 分钟给予 Muscimol hydrochloride (187 μg/kg，静脉注射)，研究Muscimol hydrochloride 对静脉注射乙酰胆碱诱导的 Ppi 增加的影响。
结果：在随后的静脉内乙酰胆碱攻击前 1 分钟，Muscimol hydrochloride （3.75–187 μg/kg） 预处理显着降低了乙酰胆碱诱导的每次测试剂量的 Ppi 增加。[4]