TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

产品编号 TMPJ-00249

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

产品编号 TMPJ-00249

规格	价格	库存	数量
20 μg	¥ 5,730	现货
100 μg	¥ 15,800	5日内发货

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产品信息

生物活性	1. Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 137.37pg/ml. (Regularly tested) 2. Immobilized Biotinylated Human TGF-beta 1-Avi at 2μg/ml (100 μl/well) can bind Human TGFBR2-Fc. The ED50 of Human TGFBR2-Fc is 9.47ng/ml. (Regularly tested)
产品描述	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
种属	Human
表达系统	HEK293 Cells
标签	N-Avi
蛋白编号	P01137
别名	转化生长因子,Transforming Growth Factor β-1,Transforming Growth Factor Beta-1,TGF-β-1,TGF-β1,TGF-Beta-1,TGFB1,TGFB,Latency-Associated Peptide,LAP
氨基酸序列	Ala279-Ser390
蛋白构建	Ala279-Ser390
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	12-18 KDa (reducing condition)
内毒素	< 10 EU/mg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Glycine-HCl, 150 mM NaCl, pH2.5.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.