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ENPP2 Protein, Mouse, Recombinant (His)

产品编号 TMPY-02055

别名: PD-Ialpha, Pdnp2, ectonucleotide pyrophosphatase/phosphodiesterase 2, PD-Iα, E-NPP 2, Npps2, lysoPLD, ATX

ENPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is Q9R1E6-1.

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ENPP2 Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 2,530		5日内发货
500 μg	￥ 16,500		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	ENPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is Q9R1E6-1.

种属	Mouse
表达系统	HEK293 Cells
标签	N-His
蛋白编号	Q9R1E6-1
别名	PD-Ialpha, Pdnp2, ectonucleotide pyrophosphatase/phosphodiesterase 2, PD-Iα, E-NPP 2, Npps2, lysoPLD, ATX
蛋白构建	The mature form of Mouse ENPP2 (Q9R1E6-1) (Ser 49-Ile 862) was fused with a polyhistidine tag at the N-terminus.
蛋白纯度	> 93 % as determined by SDS-PAGE
分子量	96 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 150 mM NaCl, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.

参考文献

1. Tania M,et al.(2010) Autotaxin: a protein with two faces. Biochem Biophys Res Commun. 401(4): 493-7. 2. Ikeda H,et al.(2009) Significance of serum autotaxin activity in gastrointestinal disease. Rinsho Byori. 57(5): 445-9. 3. Parrill AL,et al.(2008) Autotaxin inhibition: challenges and progress toward novel anti-cancer agents. Anticancer Agents Med Chem. 8(8): 917-23. 4. Pradere J.P,et al.(2007) Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase. Biochim Biophys Acta. 1771: 93-102. 5. Boucher J,et al.(2005) Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia. 48: 569-77.

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Keywords

ENPP2 Protein, Mouse, Recombinant (His) PD-Ialpha Pdnp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 PD-Iα E-NPP 2 Npps2 lysoPLD ATX recombinant recombinant-proteins proteins protein

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