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CHEK2 Protein, Human, Recombinant (GST)

产品编号 TMPY-04681

别名: CDS1, HuCds1, checkpoint kinase 2, hCds1, LFS2, RAD53, CHK2, PP1425

CHEK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 88.1 kDa and the accession number is O96017-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CHEK2 Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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生物活性	Testing in progress
产品描述	CHEK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 88.1 kDa and the accession number is O96017-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	N-GST
蛋白编号	O96017-1
别名	CDS1, HuCds1, checkpoint kinase 2, hCds1, LFS2, RAD53, CHK2, PP1425
蛋白构建	The Human CHEK2 (NP_009125.1) (Met1-Leu543) was expressed with a GST tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	88.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 50 mM Tris, 150 mM NaCl, 25%glycerol, pH 7.5, 0.1 mM EDTA, 0.5 mM TCEP.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded CHEK2 protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2s gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Bogdanova N, et al. (2005) Association of two mutations in the CHEK2 gene with breast cancer. Cancer Genetics. 116(2) : 263-6. 2. Dong XY, et al. (2003) Mutations in CHEK2 associated with prostate cancer risk. The American journal of human genetics. 72(2) 270-80. 3. Massink MPG, et al. Genomic profiling of CHEK2*1100delC-mutated breast carcinomas. BMC Cancer. 2015;15:877. doi:10.1186/s12885-015-1880-y.

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Keywords

CHEK2 Protein, Human, Recombinant (GST) LFS-2 CDS1 CHK-2 LFS 2 PP 1425 RAD 53 HuCds1 checkpoint kinase 2 RAD-53 hCds1 LFS2 CHK 2 PP-1425 RAD53 CDS 1 CDS-1 CHK2 PP1425 recombinant recombinant-proteins proteins protein

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