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KIR2DL1 Protein, Human, Recombinant (hFc)

产品编号 TMPY-02517

别名: KIR-K64, KIR221, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, XXbac-BCX195L8.1, NKAT-1, p58.1, NKAT1, XXbac-BPG184J6.7, NKAT, CD158A

KIR2DL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.7 kDa and the accession number is Q6H2H3.

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KIR2DL1 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 4,460		5日内发货

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生物活性	Testing in progress
产品描述	KIR2DL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.7 kDa and the accession number is Q6H2H3.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q6H2H3
别名	KIR-K64, KIR221, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, XXbac-BCX195L8.1, NKAT-1, p58.1, NKAT1, XXbac-BPG184J6.7, NKAT, CD158A
蛋白构建	The Human KIR2DL1 (NP_055033.2) extracellular domain (Met 1-His 245) was fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	51.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.

参考文献

1. Fan QR, et al. (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nature Immunology. 2: 452-60. 2. Wagtmann N, et al. (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2 (5): 439-49. 3. Colonna M, et al. (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science. 268 (5209): 405-8.

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Keywords

KIR2DL1 Protein, Human, Recombinant (hFc) KIR-K64 KIR 221 KIR221 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1 KIR-221 XXbac-BCX195L8.1 NKAT-1 p58.1 NKAT1 XXbac-BPG184J6.7 NKAT 1 NKAT CD158A recombinant recombinant-proteins proteins protein

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