UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) with efficacy against HER2+ breast cancer xenografts, including in cell lines resistant to anti-HER2 drugs [1]. Additionally, it functions as an inhibitor of the Filamentous temperature-sensitive protein Z (FtsZ), selectively inhibiting the growth of the Gram-positive bacterium B. subtilis with minimum inhibitory concentration (MIC) values of 100 μM, while showing no activity against the Gram-negative bacterium E. coli [2].

G28UCM 在开发的对曲妥珠单抗和拉帕替尼耐药的 HER2+ 和 FASN+ 细胞[1]中显示出细胞毒性活性。

G28UCM（40 mg/Kg；每天一次，腹腔注射；连续45天）在体内有效抑制BT474异种移植瘤的生长，且不引起体重减轻[1]。