Msr-blue

产品编号 T86932Cas号 2966537-39-1

别名

Msr-blue 是首个“Turn-on”型的甲硫氨酸亚砜还原酶 (methionine sulfoxide reductase) 荧光探针，具有超过100倍的荧光增量。Msr-blue 用于监测活细胞中甲硫氨酸亚砜还原酶的活性 (λex=340 nm, λem=440 nm)。

Msr-blue

产品编号 T86932Cas号 2966537-39-1

规格	价格	库存	数量
10 mg	询价	待询
50 mg	询价	待询

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产品介绍

生物活性

产品描述

Msr-blue, a first turn-on fluorescent probe for methionine sulfoxide reductase, exhibits a more than 100-fold fluorescence increment and is used to monitor enzyme activity in live cells (λex=340 nm, λem=440 nm) [1].

体外活性

Msr-blue emits blue fluorescence after activation by methionine sulfoxide reductase A (Msr A). Msr-blue responds to Msr A in both a time- and dose-dependent manner, with more than a 100-fold increase in emission observed. It is converted to its corresponding sulfide (15′) under catalysis by either purified Msr A or a cell lysate [1]. In a 6-OHDA-treated PC12 cellular model of Parkinson's disease (PD), Msr-blue was employed to probe Msrs function. Using Msr-blue, a decline in Msr activity in the PD model was disclosed for the first time [1].