Claudin-4 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is O14493.

Human

HEK293 Cells

WBSCR8,hCPE-R,CPETR1,CPETR,CPE-R,CPER

A DNA sequence encoding the Human CLDN4-VLP (Full Length) (O14493) (Met1-Val209) was fused with a flag tag at the C-terminus.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable in normal ovaries. Claudins form a large family of tight junction proteins that have essential roles in the control of paracellular ion flux and the maintenance of cell polarity. CLDN4 has been identified as a specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), a nontoxic molecule that may disrupt TJ barrier function and enhance cellular absorption. Claudin-4, encoding a protein for tight junction formation and function, is highly overexpressed in pancreatic ductal adenocarcinoma and is also associated with invasive adenocarcinomas arising in intraductal papillary mucinous neoplasms of the pancreas. Claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation. CLDN4 is a tight junction protein involved in blood-brain barrier integrity.