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CAIX-IN-2(Compound 9o)作为碳酸酐酶(carbonic anhydrase, CA)的抑制剂,对CAIX、CA XII和CAII的IC50分别为5.6、7.4和430 nM.此化合物能有效抑制包括HCT-116、SW480、MDA-MB 231和MCF-7在内的多种癌细胞的增殖,IC50范围在14.63-29.33 μM之间.CAIX-IN-2还能插入DNA中,阻滞G1/S期的细胞周期,促进MDA-MB-231细胞的凋亡(apoptosis)过程.此外,它也对线粒体膜电位(MMP)产生影响,提高细胞内ROS水平,引起线粒体损伤,并能抑制MDA-MB-231细胞的迁移能力.在小鼠型肿瘤模型中,CAIX-IN-2显示出明显的抗肿瘤活性.
CAIX-IN-2(Compound 9o)作为碳酸酐酶(carbonic anhydrase, CA)的抑制剂,对CAIX、CA XII和CAII的IC50分别为5.6、7.4和430 nM.此化合物能有效抑制包括HCT-116、SW480、MDA-MB 231和MCF-7在内的多种癌细胞的增殖,IC50范围在14.63-29.33 μM之间.CAIX-IN-2还能插入DNA中,阻滞G1/S期的细胞周期,促进MDA-MB-231细胞的凋亡(apoptosis)过程.此外,它也对线粒体膜电位(MMP)产生影响,提高细胞内ROS水平,引起线粒体损伤,并能抑制MDA-MB-231细胞的迁移能力.在小鼠型肿瘤模型中,CAIX-IN-2显示出明显的抗肿瘤活性.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | CAIX-IN-2 (Compound 9o) is an inhibitor of carbonic anhydrase (CA), targeting CAIX, CA XII, and CAII with IC50 values of 5.6, 7.4, and 430 nM, respectively. This compound effectively inhibits the proliferation of cancer cells such as HCT-116, SW480, MDA-MB 231, and MCF-7, with IC50 values ranging from 14.63 to 29.33 µM. CAIX-IN-2 also integrates into DNA, causing cell cycle arrest at the G1/S phase and inducing apoptosis in MDA-MB-231 cells. Furthermore, it disrupts mitochondrial membrane potential (MMP), elevates intracellular ROS levels, leading to mitochondrial damage, and inhibits the migration of MDA-MB-231 cells. In mouse models, CAIX-IN-2 has demonstrated antitumor activity. |
靶点活性 | CA Ⅸ:5.6 nM, CA XII:7.4 nM, CA Ⅱ:430 nM |
分子量 | 592.71 |
分子式 | C30H36N6O5S |
CAS No. | 3009842-92-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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