Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.

过量产生一氧化氮(NO)和前列腺素E(2)(PGE(2))会引起神经退行性疾病，如阿尔茨海默病和帕金森病。从辛夷（Magnolia fargesii, 木兰科）中分离出四种木脂素，分别为(+)-eudesmin (1)、(+)-magnolin (2)、(+)-yangambin (3)及一种新的结构，命名为Epimagnolin B (4)，它们被发现能够抑制脂多糖(LPS)激活的小胶质细胞中NO的产生[1]。