Z-WEHD-FMK

产品编号 TP2161Cas号 210345-00-9

别名

Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).

为众多的药物研发团队赋能，

让新药发现更简单！

Z-WEHD-FMK

产品编号 TP2161Cas号 210345-00-9

Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).

规格	价格	库存
5 mg	¥ 3,740	期货
10 mg	¥ 5,410	期货
50 mg	¥ 16,200	期货
100 mg	询价	期货
200 mg	询价	期货

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述

Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).

体外活性

Z-WEHD-FMK (80 μM; 9 hours) nearly completely blocks C. trachomatis-induced cleavage of golgin-84 and increases GM130 expression in cells [1]. Administered 30 minutes before exposure to E. piscicida, Z-WEHD-FMK effectively inhibits 0909I E. piscicida-induced ZF4 cell cytotoxicity and pyroptotic morphology [2]. Z-WEHD-FMK (20 μM; 18-24 hours following exposure to Cr3+, Ni2+, and Co2+) significantly reduces IL-1β release in bone marrow-derived macrophages by 76% to 86% with 200 to 400 ppm Cr3+, by 35% to 45% with 48 ppm or higher Ni2+, and below detection threshold with 6 ppm Co2+, as well as by 40% to 48% with 12 to 24 ppm Co2+ [3].

偶联与修饰

抗原信息

存储 & 运输

化学信息