IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)

产品编号 TMPY-02533

IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q16270.

IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)

产品编号 TMPY-02533

IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q16270.

规格	价格	库存
50 μg	¥ 3,170	现货
100 μg	¥ 5,130	5日内发货
200 μg	¥ 8,290	5日内发货
500 μg	¥ 15,600	5日内发货

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产品信息

生物活性	Immobilized Human IGFBP7 His at 2 μg/ml (100 μl/well) can bind Human CD93 (hFc Tag). The EC50 is 60-400 ng/ml.
产品描述	IGFBP-7 Protein, Human, Recombinant (aa 30-282, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is Q16270.
种属	Human
表达系统	HEK293 Cells
标签	N-His
蛋白编号	Q16270
别名	TAF,RAMSVPS,PSF,MAC25,insulin-like growth factor binding protein 7,IGFBPRP1,IGFBP-7v,IGFBP-7,IBP-7,FSTL2,AGM
蛋白构建	A DNA sequence encoding the human IGFBP7 (Q16270) (Asp 30-Leu 282) was fused with a polyhistidine tag at the N-terminus. Predicted N terminal: His
蛋白纯度	> 92 % as determined by SDS-PAGE
分子量	28.6 kDa (predicted); 36 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGFBP7 could inhibit cell growth, decrease soft agar colony formation activity, and induce apoptosis in RKO and SW620 cells. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity.