Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His)

Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) is expressed in in vitro E. coli expression system.

规格	价格/CNY		货期	数量
20 μg	￥ 4,960	20日内发货
100 μg	￥ 7,320	20日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 4,960

20日内发货

100 μg

￥ 7,320

20日内发货

产品描述	Cereblon/CRBN Protein, Human, Recombinant (Cell-Free, His) is expressed in in vitro E. coli expression system.

种属	Human
表达系统	E. coli
标签	C-6xHis
蛋白编号	Q96SW2
别名	CRBN, Protein cereblon
氨基酸序列	MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
蛋白构建	1-442 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	51.2 kDa (predicted)

缓冲液	Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.

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