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Asperuloside (Asperulosid) 是一种来源于蛇舌草的环烯醚萜,具有抗炎作用。它可抑制诱导型一氧化氮合酶,抑制 NF-κB 和 MAPK 信号通路。
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Asperuloside (Asperulosid) 是一种来源于蛇舌草的环烯醚萜,具有抗炎作用。它可抑制诱导型一氧化氮合酶,抑制 NF-κB 和 MAPK 信号通路。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 219 | 现货 | |
5 mg | ¥ 555 | 现货 | |
10 mg | ¥ 927 | 现货 | |
25 mg | ¥ 1,650 | 现货 | |
50 mg | ¥ 2,470 | 现货 |
产品描述 | Asperuloside (Asperulosid) has anti-inflammatory activity. |
激酶实验 | The chemiluminescent assay is used to confirm PCSEE MAO-A and MAO-B inhibitory effects and to test BNN and BVN hMAO-A and hMAO-B inhibition using MAO-Glo kit. Each enzyme's Arbitrary Light Unit (ALU) is measured in the presence of PCSEE, BNN, BVN, and standard DEP as an MAO-BI positive control. Briefly, hMAO-A and hMAO-B isozymes are diluted to 2× with reaction buffer (pH 7.4) and preincubated with 4× PCSEE, BNN, BVN, or DEP working solutions at RT for 30?min in white opaque 96-well plates. For determining activity inhibition, final 8.5?μg/mL concentrations of PCSEE, BNN, BVN, and DEP are used. For IC50 determination, 8× PCSEE and BNN working solutions are serially diluted using reaction buffers (pH 7.4) to make a 4× concentration. Ten points' range of PCSEE (1.0 to 250.0?μg/mL) and BNN (up to 400?μM (135.4?μg/mL)) final concentrations is used. Controls used are with and without ethanol. Ethanol solvent in controls is kept to a maximum final (volume) of ≤2%. Each isozyme is substituted with the reaction buffer for the blank. Based on our preliminary optimizations and Valley's method, the reaction is initiated by adding 4× luciferin derivative substrate (LDS) for a final (concentration) of 40 and 4?μM for hMAO-A and hMAO-B reactions, respectively. The final volume per well of each reaction is 50?μL. The reaction is optimized for the amount of A and B enzyme used to be incubated for less than 3.5?h at RT. To stop the reaction and produce the luminescence signal RLDR is added to all wells, 50?μL to each well, and incubated for a further 30?min. |
别名 | 车叶草苷, Asperulosid |
分子量 | 414.36 |
分子式 | C18H22O11 |
CAS No. | 14259-45-1 |
Smiles | [H][C@]12OC(=O)C3=CO[C@@]([H])(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@]([H])(C(COC(C)=O)=C1)[C@]23[H] |
密度 | 1.62 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/mL (144.8 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
---|---|---|---|---|
八仙草 | Rubiae Radix Et Rhizoma | 寒 | 苦 | 肝, 胃 |
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