N1,N11-Diethylnorspermine (DENSPM), a spermine analog, serves as a potent anticancer agent by activating polyamine catabolism, which in turn triggers cytochrome c release from mitochondria and activates caspase 3. This process ultimately leads to the death of glioblastoma multiforme (GBM) cells by inducing spermidine/spermine N1-acetyltransferase (SSAT) activity along with the production of H2O2 [1] [2] [3].

N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly reduces tumor growth in mice bearing xenografts of the DU-145 cell line [1].