SBI-581

Name: SBI-581
Brand: TargetMol
SKU: T61663
Price: -1 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T61663

SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1].

SBI-581

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产品编号 T61663

规格	价格	库存
25 mg	¥ 12,239	10-14周
50 mg	¥ 18,338	10-14周
100 mg	¥ 27,517	10-14周

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产品介绍

生物活性

产品描述	SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1].
体外活性	SBI-581 shows moderate selectivity (> 5-10x) against the majority of a broad panel of kinases [1].
体内活性	SBI-581 (10 mg/kg, IP, once) displays reasonable pharmacokinetics (t 1/2 =1.5 hr; AUC= 1202 hr*ng/mL; Cmax= ~2 μM) [1].