PROTAC-Linker Conjugates for PAC

PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.

PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC alone.

Comp Ie (MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885) 为一种新型抗体新降解剂偶联活性分子 (AnDC) 的合成降解剂偶联物。