PROTAC-Linker Conjugates for PAC

PROTAC-Antibody Conjugates (PACs) are an innovative class of therapeutic agents that combine the specificity of antibodies with the protein-degrading capabilities of PROTACs (Proteolysis-Targeting Chimeras). This combination allows for the targeted degradation of disease-causing proteins, offering a promising approach for treating various diseases, including cancer and autoimmune disorders.

PROTAC BRD4 degrader for PAC-1

T18603

PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1.

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PAC

T185142158322-33-7

PAC is a chemical conjugate consisting of an ADCs linker and PROTACs linked to an antibody. When PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) in comparison to PROTAC alone.