DR6 Protein, Mouse, Recombinant (His)

产品编号 TMPY-01421

DR6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q9EPU5.

DR6 Protein, Mouse, Recombinant (His)

产品编号 TMPY-01421

DR6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q9EPU5.

规格	价格	库存	数量
100 μg	¥ 3,820	5日内发货
1 mg	¥ 24,900	5日内发货

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产品信息

生物活性	Immobilized mouse TNFRSF21-His at 10 μg/ml (100 μl/well) can bind biotinylated human APP-Fc with a linear range of 0.31-5 μg/ml.
产品描述	DR6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is Q9EPU5.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9EPU5
别名	tumor necrosis factor receptor superfamily, member 21,TR7,R74815,DR6,AA959878
蛋白构建	A DNA sequence encoding the mouse TNFRSF21 (NP_848704.1) extracellular domain (Met 1-His 349) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Gln 42
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	35 kDa (predicted); 55-60 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.