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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 343 | 现货 | |
5 mg | ¥ 993 | 现货 | |
10 mg | ¥ 1,570 | 现货 | |
25 mg | ¥ 2,830 | 现货 | |
50 mg | ¥ 4,250 | 现货 | |
100 mg | ¥ 6,280 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 992 | 现货 |
产品描述 | CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer. |
靶点活性 | NF-κB:0.47 μM (EC50), p53:0.37 μM (EC50) |
别名 | Curaxin 137, CBLC137 |
分子量 | 336.43 |
分子式 | C21H24N2O2 |
CAS No. | 1197996-80-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (74.31 mM), Sonication is recommended. ![]() H2O: Insoluble | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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