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CC-401 Hydrochloride

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产品编号 T5833Cas号 1438391-30-0
别名 CC401 HCl

CC-401 Hydrochloride (CC401 HCl) 是 JNK 抑制剂(Ki= 25~50 nM)。

CC-401 Hydrochloride

CC-401 Hydrochloride

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纯度: 99.53%
产品编号 T5833 别名 CC401 HClCas号 1438391-30-0

CC-401 Hydrochloride (CC401 HCl) 是 JNK 抑制剂(Ki= 25~50 nM)。

规格价格库存数量
1 mg¥ 315现货
5 mg¥ 745现货
10 mg¥ 1,160现货
25 mg¥ 2,320现货
50 mg¥ 3,560现货
100 mg¥ 5,130现货
500 mg¥ 10,500现货
1 mL x 10 mM (in DMSO)¥ 818现货
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产品介绍

生物活性
产品描述
CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potential antineoplastic activity.
靶点活性
JNK:25-50 nM (Ki)
体外活性
CC-401与化疗化合物联合在结肠癌细胞系中展现出协同作用,尽管这种协同作用并非总是特异性与低氧有关。详细分析主要针对HT29和SW620(敏感)及HCT116(不敏感)细胞系。在HT29和SW620细胞中,CC-401治疗导致敏感细胞中的DNA损伤更为显著。
体内活性
在体内,通过JNK抑制增强了bevacizumab、oxaliplatin及其联合使用在HT29衍生的小鼠异种移植瘤中的效果,其中CC-401存在时的肿瘤生长延迟更为显著。最终,将一个占优势的负向JNK1构建(但不是JNK2)稳定引入HT29细胞中,使其在低氧条件下对oxaliplatin的敏感度提高,这表明JNK亚型在细胞对化疗反应中有不同的输入。
动物实验
To assess the efficacy of JNK signaling inhibition by CC-401 in anti-angiogenic and oxaliplatin combination therapy in a mouse xenograft model, adult (8-10 weeks of age) female severe combined immunodeficient mice (C.B.17 SCID) were used.?To generate tumors, HT29 cells (1 × 10^6 cells) were injected subcutaneously into the left flank of the mice.?When the tumors reached approximately 200 mm^3, mice were divided into eight groups (eight mice per group) for treatment with bevacizumab , oxaliplatin, CC401, and the appropriate combinations of bevacizumab, oxaliplatin and CC-401.?Mice in the bevacizumab treatment group received 5 mg/kg of bevacizumab by intraperitoneal injection every 3 days for 21 days.?The oxaliplatin treatment group was injected intraperitoneally with 5 mg/kg oxaliplatin per week for 2 weeks.?The CC-401 treatment group was injected intraperitoneally 25 mg/kg for every 3 days.?The combination treatment groups received bevacizumab (every 3 days, 5 mg/kg), oxaliplatin (weekly for 2 weeks, 5 mg/kg), and CC-401 (every 3 days, 25 mg/kg).?The control group received saline intraperitoneally.?Tumor volume and body weight were measured every 3 days.?Tumor volume was calculated using the formula V = AB^2/2, where A is the largest diameter and B is the smallest diameter.?Tumor growth delay was calculated as the difference in the time for control and treated tumors to grow from 200 to 800 mm^3.?For tumor growth delay calculations, mice were continued to receive treatments till the tumor volume reached 800 mm^3.?For immunohistochemistry mice were sacrificed after treatments on day 9 for tumor processing and staining.
别名CC401 HCl
化学信息
分子量424.93
分子式C22H25ClN6O
CAS No.1438391-30-0
SmilesCl.C(CN1CCCCC1)Oc1cccc(c1)-c1n[nH]c2ccc(cc12)-c1ncn[nH]1
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 100 mg/mL (235.33 mM)
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.3533 mL11.7666 mL23.5333 mL117.6664 mL
5 mM0.4707 mL2.3533 mL4.7067 mL23.5333 mL
10 mM0.2353 mL1.1767 mL2.3533 mL11.7666 mL
20 mM0.1177 mL0.5883 mL1.1767 mL5.8833 mL
50 mM0.0471 mL0.2353 mL0.4707 mL2.3533 mL
100 mM0.0235 mL0.1177 mL0.2353 mL1.1767 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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