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实体瘤靶点蛋白 (Solid Tumors Target Proteins)

在实体肿瘤方面CAR-T取得了一定的研究进展,包括食管癌、胃癌、肝癌、结直肠癌、胰腺癌、胆管癌等。与血液瘤相比,实体瘤类型繁多、致病机制多样,靶标选择难度大,在研项目的靶点较为分散。整体来看,Mesothelin、HER2、EGFR、GPC3、GD2、CD276、MUC1、Claudin 18.2(CLDN18.2)等是常见靶点。

  • Glypican 3/GPC3 Protein, Human, Recombinant (His)
    TMPY-01283
    Glypican 3 GPC3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62 kDa and the accession number is P51654-1.
    • ¥ 2830
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  • ROR1 Protein, Human, Recombinant, Biotinylated
    TMPY-04986
    ROR1 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 42.8 kDa and the accession number is Q01973.
    • ¥ 2440
    现货
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  • EGFR Protein, Human, Recombinant (His)
    TMPY-00742
    EGFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.8 kDa and the accession number is P00533-1.
    • ¥ 3820
    现货
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  • HER2/ERBB2 Protein, Human, Recombinant
    TMPY-00167
    HER2 ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
    • ¥ 4990
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  • FOLR1 Protein, Human, Recombinant (His)
    TMPY-01815
    FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1.
    • ¥ 3820
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  • EGFR Protein, Human, Recombinant (aa 668-1210, His & GST)
    TMPY-04529
    EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.1 kDa and the accession number is P00533-1.
    • ¥ 3170
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  • EpCAM/TROP1 Protein, Human, Recombinant (His)
    TMPY-01300
    EpCAM TROP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.84 kDa and the accession number is P16422.
    • ¥ 2410
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  • HER2/ERBB2 Protein, Human, Recombinant (His)
    TMPJ-00778
    HER2 ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
    • ¥ 740
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  • Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated
    TMPJ-00155
    Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. MUC-1 can act both as an adhesion and an anti-adhesion protein. This protein may provide a protective layer on epithelial cells against bacterial and enzyme attack. MUC-1 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1 influences directly or indirectly the Ras MAPK pathway. MUC-1 promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.
    • ¥ 2260
    5日内发货
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  • EpCAM/TROP1 Protein, Mouse, Recombinant (hFc)
    TMPJ-00200
    Epithelial Cellular Adhesion Molecule (Ep-CAM), also known as EGP314, mEGP314, Protein 289A, Tumor-associated calcium signal transducer 1, CD326, belongs to the EPCAM family. Its’ monomer subunit structure interacts with phosphorylated CLDN7. Ep-CAM may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It plays a role in embryonic stem cells proliferation and differentiation. It also up-regulates the expression of FABP5, MYC and cyclins A and E. The post-translational modification glycosylation at Asn-198 is crucial for protein stability.
    • ¥ 380
    5日内发货
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  • CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated
    TMPJ-01432
    MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.
    • ¥ 2260
    5日内发货
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  • EGFRVIII Protein, Human, Recombinant (His & Avi)
    TMPK-00691
    The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. EGFRVIII Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.6 kDa and the accession number is NP_001333870.1.
    • ¥ 2960
    5日内发货
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  • Nectin-4 Protein, Human, Recombinant (His & Avi)
    TMPK-00308
    Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 37.2 kDa and the accession number is Q96NY8.
    • ¥ 2660
    5日内发货
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  • CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
    TMPK-00080
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • ¥ 5180
    5日内发货
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  • ROR2 Protein, Human, Recombinant (hFc)
    TMPK-00579
    ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the development of the central nervous system. Mature human ROR2 contains a 369 amino acid (aa) extracellular domain (ECD) and a 518 aa cytoplasmic tail containing an tyrosine kinase domain. ROR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 68 kDa and the accession number is A1L4F5.
    • ¥ 3100
    5日内发货
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  • B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)
    TMPK-01017
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q5ZPR3-2.
    • ¥ 2360
    5日内发货
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  • EpCAM/TROP1 Protein, Human, Recombinant (aa 24-265, hFc)
    TMPK-00206
    Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1 4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain. EpCAM TROP1 Protein, Human, Recombinant (aa 24-265, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 54.2 kDa and the accession number is P16422.
    • ¥ 1920
    5日内发货
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  • B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
    TMPK-00314
    B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) B7-H3b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.5 kDa and the accession number is Q5ZPR3-1.
    • ¥ 2660
    5日内发货
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  • HGFR/c-Met Protein, Cynomolgus, Recombinant (His)
    TMPK-00499
    c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR c-Met Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.5 kDa (α chain) and 69.9 kDa (β chain) and the accession number is A0A2K5UM36.
    • ¥ 3100
    5日内发货
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  • CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated
    TMPK-01366
    CA125 MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
    • ¥ 5180
    5日内发货
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  • Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)
    TMPH-01705
    Mucin-1 MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
    • ¥ 1510
    20日内发货
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  • HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)
    TMPY-00636
    HER2 ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
    • ¥ 3820
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  • EpCAM/TROP1 Protein, Mouse, Recombinant (His)
    TMPY-01766
    EpCAM TROP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.1 kDa and the accession number is Q99JW5.
    • ¥ 2300
    5日内发货
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  • HGFR/c-Met Protein, Canine, Recombinant (His)
    TMPY-02068
    HGFR c-Met Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is Q75ZY9.
    • ¥ 3820
    5日内发货
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  • HER2/ERBB2 Protein, Rhesus, Recombinant (hFc)
    TMPY-01945
    HER2 ERBB2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.3 kDa and the accession number is XP_001090430.1.
    • ¥ 3820
    5日内发货
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  • FOLR1 Protein, Canine, Recombinant (hFc)
    TMPY-02417
    FOLR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.7 kDa and the accession number is A0A8C0Z2T7.
    • ¥ 3820
    5日内发货
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  • EGFR Protein, Mouse, Recombinant (hFc)
    TMPY-02675
    EGFR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96 kDa and the accession number is Q01279.
    • ¥ 3820
    5日内发货
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  • EGFR Protein, Mouse, Recombinant (His)
    TMPY-02676
    EGFR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is Q01279.
    • ¥ 3820
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  • EGFR Protein, Rat, Recombinant (His)
    TMPY-02958
    EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.
    • ¥ 3820
    5日内发货
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  • CD70 Protein, Rat, Recombinant (hFc)
    TMPY-03129
    CD70 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is D3ZGU3.
    • ¥ 3430
    5日内发货
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  • NKG2D/CD314 Protein, Human, Recombinant (aa 78-216, His)
    TMPY-03256
    NKG2D CD314 Protein, Human, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.4 kDa and the accession number is P26718-1.
    • ¥ 3820
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  • NKG2D/CD314 Protein, Rhesus, Recombinant (aa 78-216, His)
    TMPY-03376
    NKG2D CD314 Protein, Rhesus, Recombinant (aa 78-216, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 18.3 kDa and the accession number is P61252.
    • ¥ 3820
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  • VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
    TMPY-04802
    VEGFR2 KDR Protein, Human, Recombinant (Domain 2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.4 kDa and the accession number is P35968-1.
    • ¥ 6390
    5日内发货
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  • EGFR Protein, Cynomolgus, Recombinant (His)
    TMPY-04818
    EGFR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is A0A2K5WK39.
    • ¥ 2520
    现货
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  • EGFR Protein, Human, Recombinant (Isoform Viii, hFc)
    TMPY-05258
    EGFR Protein, Human, Recombinant (Isoform Viii, hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is NP_001333870.1.
    • ¥ 2530
    5日内发货
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  • EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05587
    EpCAM TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 30.7 kDa and the accession number is P16422.
    • ¥ 2930
    现货
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  • TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His)
    TMPY-05153
    TROP-2 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.7 kDa and the accession number is XP_001114599.1.
    • ¥ 2330
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  • VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
    TMPY-05657
    VEGFR2 KDR Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
    • ¥ 1950
    5日内发货
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  • EpCAM/TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-05601
    EpCAM TROP1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 56 kDa and the accession number is P16422.
    • ¥ 2940
    5日内发货
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  • EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated
    TMPY-05612
    EGFR Protein, Human, Recombinant (aa 1-645, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 71.9 kDa and the accession number is P00533-1.
    • ¥ 2940
    5日内发货
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  • EpCAM/TROP1 Protein, Human, Recombinant (hFc), Biotinylated
    TMPY-05117
    EpCAM TROP1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is P16422.
    • ¥ 1950
    5日内发货
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  • VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05610
    VEGFR2 KDR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 86.5 kDa and the accession number is P35968-1.
    • ¥ 2940
    5日内发货
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  • ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05603
    ROR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.2 kDa and the accession number is Q01973.
    • ¥ 2940
    5日内发货
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  • EpCAM/TROP1 Protein, Cynomolgus, Rhesus, Recombinant
    TMPY-00534
    EpCAM TROP1 Protein, Cynomolgus, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 28 kDa and the accession number is G7PM59.
    • ¥ 3820
    5日内发货
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  • EpCAM/TROP1 Protein, Rat, Recombinant (hFc)
    TMPY-03003
    EpCAM TROP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.8 kDa and the accession number is O55159.
    • ¥ 3820
    5日内发货
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  • HGFR/c-Met Protein, Human, Recombinant (aa 956-1390, His & GST)
    TMPY-04379
    HGFR c-Met Protein, Human, Recombinant (aa 956-1390, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P08581-1.
    • ¥ 3170
    5日内发货
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  • ROR1 Protein, Human, Recombinant (hFc)
    TMPY-04068
    ROR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69 kDa and the accession number is Q01973.
    • ¥ 1410
    5日内发货
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  • CA125/MUC16 Protein, Human, Recombinant (His)
    TMPY-06614
    CA125 MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1.
    • ¥ 3820
    5日内发货
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