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LP23为非芳基甲胺类PD-1/PD-L1抑制剂(IC50:16.7 nM),展现出抗肿瘤效果。能恢复HepG2/Jurkat T细胞的免疫功能并促进HepG2细胞凋亡。在B16-F10肿瘤模型中,LP23表现出体内活性,在剂量为30 mg/kg时TGI达到88.6%。
LP23为非芳基甲胺类PD-1/PD-L1抑制剂(IC50:16.7 nM),展现出抗肿瘤效果。能恢复HepG2/Jurkat T细胞的免疫功能并促进HepG2细胞凋亡。在B16-F10肿瘤模型中,LP23表现出体内活性,在剂量为30 mg/kg时TGI达到88.6%。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/Jurkat T cells and induction of HepG2 cell death. Additionally, LP23 demonstrates in vivo efficacy in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg) [1]. |
分子量 | 505.59 |
分子式 | C27H27N3O5S |
存储 | Shipping with blue ice. |
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