按潜在通路靶点分类

ChemDiv开发了RNA等位三核苷酸模拟物库，该化合物库包含29000个小分子化合物，专门用于靶向RNA 扩展重复序列。

ChemDiv’s RNA-Protein Interaction Inhibitors Library contains 2,111 compounds.

Life Chemicals has developed its RNA Screening Library of over 4,400 drug-like compounds with predicted RNA-binding activity as an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

含2.1万种潜在活性小分子化合物，是表观转录组学、免疫系统和中枢神经系统疾病相关研究的有力工具。

Life Chemicals has designed a library of potential GPCR modulators based on known structure and activity data for GPCR targeting compounds available publicly.

Life Chemicals offers its new Chelator Library (over 5,700 compounds) that is based on a variety of metal-binding groups.

The Matrix Metalloproteinase Focused Library contains over 2,000 screening compounds.

Cysteine Protease Focused Library comprises over 3,700 screening compounds with potential inhibitory activity against cysteine proteases.

Over 17,000 structurally diverse molecules with potential polymerase inhibition activity.

Life Chemicals has designed a new Tyrosine Kinase Screening Library of about 5,700 drug-like screening compounds offered for high throughput screening (HTS).

Serine proteases are one of the most biologically important families of proteins that have been shown to play multifarious roles in various diseases (such as cancer proliferation, auto-immune disorders, and allergy).

Antimycobacterial library in Otava contains 1696 compounds

Tryptase targeted library in Otava contains 139 compounds

ChemDiv’s MCL1 Targeted Library contains 12,000 compounds.

共价丝氨酸水解酶库包含12160种化合物。

Protease Library contains 6640 compounds

冠状病毒筛选库包含2019-nCoV主要蛋白酶靶向库、eEF1A靶向库、2019-nCoV木瓜样蛋白酶靶向库、SARS冠状病毒重点库

ChemDiv’s Bcl2-PPI Inhibitors Library contains 11,000 compounds.

Tubulin Inhibitors library in UORSY contains 2003 compounds.

Sphingosine kinase inhibitor library in Otava contains 1119 compounds

GPCR antagonist general library in Otava contains 5089 compounds

NADH kinase inhibitor library in Otava contains 871 compounds

iPPI Bayesian Library with 2637 compounds was prepared using Bayesian modeling (ECFP6 and FCFP6 fingerprints) based on known active PPI inhibitors (IC50<100 nM) taken from the TIMBAL database.

The database contains 190k small molecules divided into 23 sub libraries each focused at a specific target. According to the recent studies, molecules acting on a particular target or class of targets usually have characteristic moieties (PF) containing key binding points responsible for activity, e.g. hinge-binding fragments. We used this principle for the statistical analysis of the reported active molecules and corresponding targets for the annotation of pre-filtered ChemDiv in house collection. The library includes the following targets: Enzymes: Aminoacyltransferase, Hydrolases, Isomerases, Kinases, Ligases, Lyases, Oixireductases, Phosphatases, Proteases, Transferases, Phosphodiesterases; Membrane Receptors: βAmyloid A4 protein, Family A GPCR, Family B GPCR, Family C GPCR, Frizzled family GPCR, Taste family GPCR, σOpioid receptor, Thrombopoietin receptor; Ion channels: Voltage-gated, Ligand-gated; Epigenetic regulator.

OTAVAchemicals offers SARS-CoV-2 RNA-dependent RNA Polymerase (RdRp) Targeted Library, which contains 1031 compounds with predicted activity against SARS-CoV-2 RdRp.

ChemDiv’s Antimitotic Tubulin Library contains 18,000 compounds.

We have designed an MDM2-targeted library of more than 23K small molecule compounds.

OTAVAchemicals offers Transporter Modulators Library (525 compounds).

Adenosine receptor antagonist library in Otava contains 110 compounds

Proteases modulators library contains 2500 compounds.

OTAVAchemicals offers Selective Androgen Receptor Modulators-Like Library (1233 compounds in total).

Life Chemicals has designed a Library of over 3,900 drug-like screening compounds that are small-molecule analogs of known ligase inhibitors with experimentally determined activity.

CB2 Focused Library in the Princeton BioMolecal Research contains 1770 compounds.

Lombricine kinase inhibitor library in Otava contains 163 compounds

ChemDiv’s Proline Kinase Library contains 2,000 compounds.

ChemDiv’s Autophagy-Targeted Library contains 4,550 compounds.

Over 2,500 screening compounds of potential helicase inhibitors were selected, with the most active compounds placed at the top of the list.

HCV serine protease targeted library in Otava contains 1300 compounds

PKC Focused Library in the Princeton BioMolecal Research contains 123 compounds.

The Life Chemicals Receptor-based Screening Library contains over 2,000 potential lysine-specific demethylase 4A (KDM4A) inhibitors selected with computational chemistry and virtual screening techniques. The Library presented is a rich source of inhibitors for screening projects in KDM-related drug discovery.

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Blocker library (657 compounds in total) was designed as a special screening library containing compounds with predicted HCN channels blocking activity and selectivity.