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4-hydroperoxy cyclophosphamide (4-OOH-CY) 是 Cyclophosphamide 的活性代谢物,可诱导肝毒性。4-Hydroperoxy cyclophosphamide 可增加谷丙转氨酶和天冬氨酸转氨酶水平,增强炎症因子和氧化指标,抑制氧化还原酶活性。4-hydroperoxy cyclophosphamide 可用于研究癌症和自身免疫疾病。
4-hydroperoxy cyclophosphamide (4-OOH-CY) 是 Cyclophosphamide 的活性代谢物,可诱导肝毒性。4-Hydroperoxy cyclophosphamide 可增加谷丙转氨酶和天冬氨酸转氨酶水平,增强炎症因子和氧化指标,抑制氧化还原酶活性。4-hydroperoxy cyclophosphamide 可用于研究癌症和自身免疫疾病。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,610 | 现货 |
产品描述 | 4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases. |
体外活性 | 4-hydroperoxy cyclophosphamide 通过氧化应激诱导的线粒体凋亡因子 AIF 和 EndoG 的核重新定位介导 caspase 非依赖性 T 细胞凋亡。[1] 1 μg/mL 4-hydroperoxy cyclophosphamide 和甲氨蝶呤联用通过抑制 JAK2/STAT3 和 p38MAPK 信号通路抑制 IL-6/sil-6r 诱导的成纤维细胞样滑膜细胞中 RANKL 的表达。[2] |
体内活性 | 腹腔注射200 mg/kg 4-hydroperoxy cyclophosphamide 导致在小鼠中不依赖 caspase 的 T 细胞和 B细胞死亡。[1] |
别名 | 培磷酰胺, 4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide |
分子量 | 293.09 |
分子式 | C7H15Cl2N2O4P |
CAS No. | 39800-16-3 |
Smiles | O=P1(OCCC(OO)N1)N(CCCl)CCCl |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | Dichloromethane: <1 mg/mL(insoluble or slightly soluble) DMSO: 30 mg/mL(102.36 mM), Sonication is recommended. Chloroform: <1 mg/mL(insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
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