PF-06747711

Name: PF-06747711
Brand: TargetMol
SKU: T16495
Rating: 4.5 (1 reviews)

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产品编号 T16495Cas号 1892576-58-7

PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.

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PF-06747711

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产品编号 T16495Cas号 1892576-58-7

PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.

规格	价格	库存
2 mg	¥ 648	5日内发货
25 mg	¥ 4,480	8-10周
50 mg	¥ 5,820	8-10周
100 mg	¥ 9,570	8-10周
1 mL x 10 mM (in DMSO)	¥ 1,250	5日内发货

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产品介绍

生物活性

产品描述	PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.
靶点活性	RORC2:4.1 nM
体外活性	PF-06747711 decreases IL-17 production by human Th17 cells (IC50: 9.5 nM) [1].
体内活性	In mice, PF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) suppresses ear swelling in a dose-dependent manner[1].

化学信息

分子量	497.51
分子式	C₂₆H₂₆F₃N₅O₂
CAS No.	1892576-58-7
密度	1.34 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 41.67 mg/mL (83.76 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0100 mL	10.0500 mL	20.1001 mL	100.5005 mL
5 mM	0.4020 mL	2.0100 mL	4.0200 mL	20.1001 mL
10 mM	0.2010 mL	1.0050 mL	2.0100 mL	10.0500 mL
20 mM	0.1005 mL	0.5025 mL	1.0050 mL	5.0250 mL
50 mM	0.0402 mL	0.2010 mL	0.4020 mL	2.0100 mL