HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-07027

HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P08581-1.

HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-07027

HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P08581-1.

规格	价格	库存	数量
25 tests	¥ 2,930	期货
100 tests	¥ 9,870	期货

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产品信息

生物活性	1. Flow cytometric analysis of anti-c-MET CAR expression. 293 cells were lentivirally transduced with anti-c-MET CAR. Flow cytometric analysis was performed with a negative control protein and HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled (Cat#TMPY-07027), respectively. Non-transduced 293 cells were used as a control (left). 2. Binding activity of PE-conjugated c-MET protein to PBMC cells. PBMC cells were stained with anti-CD3 antibody and HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled (Cat#TMPY-07027) and detected by flow cytometry. PBMC cells stained with anti-CD3 antibody were used as a control (left).
产品描述	HGFR/c-Met Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P08581-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P08581-1
别名	RCCP2,HGFR,DFNB97,DA11,c-Met,AUTS9
蛋白构建	A DNA sequence encoding the Human MET (NP_000236.2) (Met1-Thr932) was expressed with a polyhistidine tag at the C-terminus. The protein is site-specifically labeled with PE (Excitation = 495-566 nm, Emission Max. = 575 nm).
分子量	105.1 kDa (predicted)
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method
缓冲液	This product is Lyophilized from sterile PBS, 0.2% BSA, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法	Please refer to the lot-specific COA.
存储	Twelve months from date of receipt at -20℃ to -70℃ in lyophilized form and 3 months at -70℃ under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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