HER2-IN-10 is a psoralen derivative that induces apoptosis. HER2-IN-10 shows anti-breast cancer activity and light-activated cytotoxicity [1].

HER2-IN-10 (50 μM) has phototoxicity against SK-BR-3 cells with the IC 50 of 3.05 μM [1]. HER2-IN-10 (1-50 μM; 48 h) changes the morphology of the SK-BR-3 cells under UVA irradiation and increases the apoptotic index [1]. Apoptosis Analysis [1] Cell Line: SK-BR-3 cells Concentration: 1, 2.5, 5, 10, 20 and 50 μM Incubation Time: 48 hours Result: Broken down cells into apoptotic bodies at higher concentrations (10, 20, and 50 μM) and cell shrinkage, plasma membrane blebbing at lower concentrations (1, 2.5, and 5 μM).