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受体丝氨酸/苏氨酸激酶 (Receptor Serine/Threonine Kinases)

受体丝氨酸/苏氨酸激酶(Receptor Serine/Threonine Kinases)是单次跨膜蛋白受体,在胞内区具有丝氨酸/苏氨酸蛋白激酶活性,该受体以异二聚体行使功能。主要使下游信号蛋白中的丝氨酸或苏氨酸磷酸化,把细胞外的信号传入细胞内,再通过影响基因转录来达到多种生物学功能。

筛选 首页 重组蛋白 (Recombinant Protein)受体蛋白 (Receptor Proteins)受体丝氨酸/苏氨酸激酶 (Receptor Serine/Threonine Kinases)
  • TGFBR1 Protein, Human, Recombinant (mFc & Avi)
    TMPK-00305
    transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1.
    • ¥ 3980
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  • TGFBR2 Protein, Human, Recombinant (His)
    TMPY-05157
    TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.
    • ¥ 3170
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  • TGFBR1 Protein, Mouse, Recombinant (hFc)
    TMPJ-01178
    TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.
    • ¥ 890
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  • ALK-2/ACVR1 Protein, Human, Recombinant (His & hFc)
    TMPY-00658
    ALK-2 ACVR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is D3DPA4.
    • ¥ 5750
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  • ALK-4/ACVR1B Protein, Human, Recombinant (His)
    TMPY-01293
    ALK-4 ACVR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P36896-1.
    • ¥ 3820
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  • ALK-5 Protein, Human, Recombinant (His & hFc)
    TMPY-01358
    ALK-5 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36897-1.
    • ¥ 3170
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  • BMPR1A/ALK-3 Protein, Canine, Recombinant (hFc)
    TMPY-00614
    BMPR1A ALK-3 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is A0A8C0S7K5.
    • ¥ 2530
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  • BMPR1A/ALK-3 Protein, Mouse, Recombinant (His & hFc)
    TMPY-00962
    BMPR1A ALK-3 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is P36895.
    • ¥ 4460
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  • ALK-1 Protein, Cynomolgus, Recombinant (His)
    TMPY-00310
    ALK-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is A0A2K5WXU2.
    • ¥ 3820
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  • ALK-4/ACVR1B Protein, Rhesus, Recombinant (hFc)
    TMPY-03100
    ALK-4 ACVR1B Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is I2CYX8.
    • ¥ 3820
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  • TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated
    TMPY-05810
    TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P37173.
    • ¥ 2440
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  • ALK-5 Protein, Human, Recombinant (hFc)
    TMPY-05771
    ALK-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.87 kDa and the accession number is P36897-1.
    • ¥ 2270
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  • TGFBR2 Protein, Human, Recombinant (hFc)
    TMPY-05508
    TGFBR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is P37173.
    • ¥ 2530
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  • BMPRIB Protein, Human, Recombinant (hFc)
    TMPY-03362
    BMPRIB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.7 kDa and the accession number is O00238-1.
    • ¥ 5750
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  • BMPRIB Protein, Human, Recombinant (aa 149-502, His & GST)
    TMPY-04367
    BMPRIB Protein, Human, Recombinant (aa 149-502, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is O00238-1.
    • ¥ 3170
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  • p38 gamma/MAPK12 Protein, Human, Recombinant
    TMPY-04430
    p38 gamma MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
    • ¥ 3170
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  • p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)
    TMPY-04429
    p38 gamma MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
    • ¥ 3170
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  • TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc)
    TMPJ-00333
    TGFBR2 Protein, Mouse, Recombinant (aa 24-184, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-75 KDa and the accession number is Q62312.
    • ¥ 890
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  • ALK-2/ACVR1 Protein, Human, Recombinant (hFc)
    TMPJ-01158
    Activin RIA, also known as ALK-2, TSK-7L, SKR1, TSR-I, and ACTR-I, is a glycosylated 65 kDa type I receptor in the TGF-beta serine threonine kinase receptor family. Binding of TGF-beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins. Activin RIA functions in a wide variety of growth and differentiation processes including gastrulation, skeletal system development, and cardiac morphogenesis. BMP signaling through Activin RIA is enhanced by the direct interaction between Activin RIA and RGM-B DRAGON, a BMP coreceptor that also associates with other type I and type II receptors. Activin RIA can additionally phosphorylate the coreceptor Endoglin and is required for the inhibitory effect of Endoglin on prostate cancer cell motility.
    • ¥ 350
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  • BMPR1A/ALK-3 Protein, Mouse, Recombinant (His)
    TMPY-01374
    BMPR1A ALK-3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is P36895.
    • ¥ 4460
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  • ALK-1 Protein, Rat, Recombinant (His & hFc)
    TMPY-00757
    ALK-1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.7 kDa and the accession number is A6KCN1.
    • ¥ 5750
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  • BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)
    TMPY-05485
    BMPR1A ALK-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.9 kDa and the accession number is P36894.
    • ¥ 2530
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  • ALK-4/ACVR1B Protein, Human, Recombinant (hFc)
    TMPY-05483
    ALK-4 ACVR1B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.1 kDa and the accession number is P36896-1.
    • ¥ 5750
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  • TEM8/ANTXR1 Protein, Human, Recombinant (hFc)
    TMPY-02953
    ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins complexes (ATRIP for ATR; MRN for ATM), ATM ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. ANTXR1 interacts with extracellular matrix proteins and with the actin cytoskeleton. It functions in cell attachment and migration. ANTXR1 also mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
    • ¥ 3820
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  • TGFBR2 Protein, Rat, Recombinant (hFc)
    TMPY-03082
    TGFBR2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is P38438.
    • ¥ 3820
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  • TGFBR3 Protein, Human, Recombinant (His)
    TMPY-03649
    TGFBR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 42.2 kDa and the accession number is Q03167-1.
    • ¥ 3820
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  • ALK-1 Protein, Human, Recombinant (hFc)
    TMPY-00650
    ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310.
    • ¥ 3170
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  • TGFBR2 Protein, Mouse, Recombinant (His)
    TMPJ-00335
    TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
    • ¥ 570
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  • BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)
    TMPJ-00325
    Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A is a single-pass type I membrane protein and highly expressed in skeletal muscle. BMPR1A contains one GS domain and one protein protein kinase domain. BMPR1A is necessary for the extracellular matrix depostition by osteoblasts. BMPR1A can activate SMAD transcriptional regulators, binding with ligands. Defects in BMPR1A are a cause of juvenile polyposis syndrome, Cowden disease and hereditary mixed polyposis syndrome 2 (HMPS2).
    • ¥ 380
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  • ALK-1 Protein, Mouse, Recombinant (hFc)
    TMPJ-00304
    Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
    • ¥ 220
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  • ALK-4/ACVR1B Protein, Mouse, Recombinant (hFc)
    TMPY-00444
    ALK-4 ACVR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is Q3TZF1.
    • ¥ 3820
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  • TGFBR2 Protein, Rhesus, Recombinant (hFc)
    TMPY-03171
    TGFBR2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.4 kDa and the accession number is H9YUL0.
    • ¥ 3170
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  • ALK-1 Protein, Cynomolgus, Recombinant (hFc)
    TMPY-03315
    ALK-1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.8 kDa.
    • ¥ 5750
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  • ALK-4/ACVR1B Protein, Rat, Recombinant (hFc)
    TMPY-03300
    ALK-4 ACVR1B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.4 kDa and the accession number is P80202.
    • ¥ 3820
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  • ALK-1 Protein, Canine, Recombinant (hFc)
    TMPY-03678
    ALK-1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 12.2 kDa and the accession number is E2R174.
    • ¥ 5750
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  • Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)
    TMPY-04406
    Serine threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser Thr protein kinase family and PKD subfamily. PRKD2 PKD2 is widely expressed. It contains one PH domain, two phorbol-ester DAG-type zinc fingers and one protein kinase domain. PRKD2 PKD2 is activated by DAG and phorbol esters. Phorbol-ester DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 and phosphorylation of Ser-76 by PKC relieves auto-inhibition by the PH domain. PRKD2 PKD2 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.
    • ¥ 3170
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  • ALK-1 Protein, Human, Recombinant (His)
    TMPY-01168
    ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
    • ¥ 3170
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  • TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc)
    TMPJ-00334
    TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2.
    • ¥ 580
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  • AMHRII Protein, Human, Recombinant
    TMPK-00976
    The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women undergoing medically assisted reproduction. Three hundred in vitro fertilization or intracytoplasmic sperm injection patients constituted the study population, while 300 women with at least one spontaneous pregnancy participated as controls. AMHRII Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.3 kDa and the accession number is Q16671-1.
    • ¥ 3400
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  • TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
    TMPK-00329
    The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 44 kDa and the accession number is P37173-1.
    • ¥ 5180
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  • TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
    TMPK-00306
    transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1.
    • ¥ 5180
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  • ALK-2/ACVR1 Protein, Mouse, Recombinant (His & hFc)
    TMPY-01096
    ALK-2 ACVR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 40 kDa and the accession number is P37172.
    • ¥ 5750
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  • ALK-7 Protein, Human, Recombinant (hFc)
    TMPY-00486
    ALK-7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is Q8NER5-1.
    • ¥ 5750
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  • ALK-2/ACVR1 Protein, Cynomolgus, Recombinant (hFc)
    TMPY-03247
    ALK-2 ACVR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.2 kDa and the accession number is F7A9J8.
    • ¥ 5750
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  • ALK-2/ACVR1 Protein, Rat, Recombinant (hFc)
    TMPY-03157
    ALK-2 ACVR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.5 kDa and the accession number is P80201.
    • ¥ 5750
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  • ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)
    TMPY-04366
    ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.6 kDa and the accession number is P36897-1.
    • ¥ 3170
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  • ALK-2/ACVR1 Protein, Canine, Recombinant (hFc)
    TMPY-03706
    ALK-2 ACVR1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.6 kDa and the accession number is A0A8C0MPL7.
    • ¥ 5750
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  • TGFBR3 Protein, Mouse, Recombinant (His)
    TMPY-02224
    TGFBR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.3 kDa and the accession number is A0A0R4J097.
    • ¥ 3820
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