FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in CHO mammalian cells with C-His-Avi tag. The predicted molecular weight is 61.20 kDa and the accession number is P36888-1.

Human

CHO Cells

STK-1,FLT-3,FLK2,CD135

Asn27-Asn541

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.