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VSIG4 Protein, Human, Recombinant (hFc), Biotinylated

产品编号 TMPY-05370

VSIG4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.2 kDa and the accession number is Q9Y279-1.

VSIG4 Protein, Human, Recombinant (hFc), Biotinylated

VSIG4 Protein, Human, Recombinant (hFc), Biotinylated

产品编号 TMPY-05370
VSIG4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.2 kDa and the accession number is Q9Y279-1.
规格价格库存数量
20 μg¥ 1,9505日内发货
100 μg¥ 4,6205日内发货
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产品信息

生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述
VSIG4 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.2 kDa and the accession number is Q9Y279-1.
种属
Human
表达系统
HEK293 Cells
标签C-hFc
蛋白编号Q9Y279-1
别名
Z39IG,V-set and immunoglobulin domain containing 4,CRIg
蛋白构建
A DNA sequence encoding the human VSIG4 (NP_009199.1) (Met1-Pro283) was expressed with the Fc region of human IgG1 at the C-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Arg 20
蛋白纯度
> 90 % as determined by SDS-PAGE
分子量56.2 kDa (predicted)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 28 amino acid precursor that contains a signal sequence, a V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 8% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.

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