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ITSA-1 是一种具有膜渗透性的HDAC 激活剂,抵消曲古抑菌素 A (TSA) 诱导的细胞周期停滞,组蛋白乙酰化和转录水平。
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ITSA-1 是一种具有膜渗透性的HDAC 激活剂,抵消曲古抑菌素 A (TSA) 诱导的细胞周期停滞,组蛋白乙酰化和转录水平。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 257 | 现货 | |
10 mg | ¥ 413 | 现货 | |
25 mg | ¥ 690 | 现货 | |
50 mg | ¥ 997 | 现货 | |
100 mg | ¥ 1,830 | 现货 | |
200 mg | ¥ 2,450 | 现货 | |
500 mg | ¥ 4,150 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 438 | 现货 |
产品描述 | ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors. |
细胞实验 | A549 cells ( 75% confluent) in 10-cm dishes are treated with DMSO (0.1%), TSA (500 nM), or tubacin (2 μM) for 4.5 h, and then either DMSO (0.1%) or ITSA1 (50 μM) is added for an additional 17.5 h. Samples are rinsed in PBS, trypsinized, and fixed for 2 h in 70% ethanol 30% PBS (4°C). Cells then are washed once in PBS and stored overnight in PBS (4°C).(Only for Reference) |
别名 | ITSA1 |
分子量 | 292.12 |
分子式 | C13H7Cl2N3O |
CAS No. | 200626-61-5 |
Smiles | Clc1ccc(C(=O)n2nnc3ccccc23)c(Cl)c1 |
密度 | 1.51g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/mL (205.4 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 5 mg/mL (17.12 mM) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
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