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RMC-3943
还可以产品编号 T39221Cas号 1801764-60-2
RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM.
RMC-3943
还可以产品编号 T39221Cas号 1801764-60-2
RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 10,600 | 6-8周 |
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生物活性
化学信息
| 产品描述 | RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM. |
| 体外活性 | RMC-3943 inhibits pERK in PC9 cells, with an IC 50 of 35.5 nM[1]. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1]. Cell Viability Assay Cell Line: SK-MEL-113 cells[1]. Concentration: 0-10 μM. Incubation Time: 7 days. Result: Inhibited cell proliferation. |
| 分子量 | 425.38 |
| 分子式 | C18H22Cl2N6S |
| CAS No. | 1801764-60-2 |
| 密度 | 1.47 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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