ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuberculosis chemotherapy.

Non-replicatingMycobacterium tuberculosis bacilli:1 μM (IC90), Non-replicatingMycobacterium tuberculosis bacilli:4 μM (IC99)

ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC 90 of 1 μM. Additionally, ML338?have an IC 99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs[1].ML338? (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration[1].ML338?is against the non-replicating M. tuberculosis with IC 90 and IC 99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating?M. tuberculosis with IC 90 and IC 99 velues of 62 μM and 62 μM, respectively by CFU[1].