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Antitumor agent-172 (Compound 28),作为β-catenin/BCL9相互作用的抑制剂,展示了IC50值为3.92 μM的效果。其对β-catenin的高亲和性体现在Kd值仅为82 nM。此外,Antitumor agent-172 能够有效激活T细胞和促进抗原呈递,同时在小鼠模型中显示出显著的抗肿瘤活性及优异的药代动力学属性。
Antitumor agent-172 (Compound 28),作为β-catenin/BCL9相互作用的抑制剂,展示了IC50值为3.92 μM的效果。其对β-catenin的高亲和性体现在Kd值仅为82 nM。此外,Antitumor agent-172 能够有效激活T细胞和促进抗原呈递,同时在小鼠模型中显示出显著的抗肿瘤活性及优异的药代动力学属性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Antitumor agent-172 (Compound 28) acts as an inhibitor of the β-catenin/BCL9 interaction, featuring an IC50 of 3.92 μM. This compound exhibits high affinity for β-catenin, with a Kd of 82 nM. Furthermore, Antitumor agent-172 activates T cells, enhances antigen presentation, and demonstrates antitumor activity along with favorable pharmacokinetic properties in murine models. |
分子量 | 670.84 |
分子式 | C37H50N8O4 |
CAS No. | 3027905-74-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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