GDF-15 Protein, Human, Recombinant (hFc)

GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988.

规格	价格/CNY		数量
50 μg	￥ 1,950	现货
100 μg	￥ 3,320	5日内发货
200 μg	￥ 5,670	5日内发货
500 μg	￥ 11,490	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 1,950

现货

100 μg

￥ 3,320

5日内发货

200 μg

￥ 5,670

5日内发货

500 μg

￥ 11,490

5日内发货

生物活性	Testing in progress
产品描述	GDF-15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is Q99988.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	Q99988
别名	PTGFB, PLAB, MIC-1, MIC1, PDF, NAG-1, growth differentiation factor 15, GDF-15
蛋白构建	The mature form of Human GDF15 (NP_004855.2) (Ala 197-Ile 308) was expressed with the fused Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	40.6 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.