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Cyclopentenylcytosine(CPC)是一种核苷类似物,通过抑制CTP合成酶来降低白血病细胞中的胞苷三磷酸(CTP)和脱氧胞苷三磷酸(dCTP)水平。此外,Cyclopentenylcytosine 促进 1-β-D-阿拉伯核糖甘露苷胞苷(araC)的磷酸化并增加其插入DNA的活性。Cyclopentenylcytosine 以浓度(50-300 nM)和时间依赖(8-16小时)的方式诱导人T淋巴细胞系MOLT-3的凋亡和坏死。Cyclopentenylcytosine与araC联合使用可以增强对凋亡和坏死的诱导作用及其在T淋巴母细胞中的细胞毒性。
Cyclopentenylcytosine(CPC)是一种核苷类似物,通过抑制CTP合成酶来降低白血病细胞中的胞苷三磷酸(CTP)和脱氧胞苷三磷酸(dCTP)水平。此外,Cyclopentenylcytosine 促进 1-β-D-阿拉伯核糖甘露苷胞苷(araC)的磷酸化并增加其插入DNA的活性。Cyclopentenylcytosine 以浓度(50-300 nM)和时间依赖(8-16小时)的方式诱导人T淋巴细胞系MOLT-3的凋亡和坏死。Cyclopentenylcytosine与araC联合使用可以增强对凋亡和坏死的诱导作用及其在T淋巴母细胞中的细胞毒性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Cyclopentenylcytosine (CPC), a nucleoside analog, effectively inhibits CTP synthetase, leading to reduced levels of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells. Furthermore, it enhances the phosphorylation of 1-β-D-arabinorubosylmannosylcytidine (araC) and increases its DNA intercalation activity. In the human T lymphocyte line MOLT-3, cyclopentenylcytosine triggers apoptosis and necrosis in a dose (50-300 nM) and time (8-16 h) dependent manner. When used in conjunction with araC, cyclopentenylcytosine augments the induction of both apoptosis and necrosis, amplifying its cytotoxic effects on T lymphoblasts . |
别名 | CPEC |
分子量 | 239.23 |
分子式 | C10H13N3O4 |
CAS No. | 90597-22-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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