Kremen-1 Protein, Human, Recombinant (His)

产品编号 TMPY-04144

KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.

Kremen-1 Protein, Human, Recombinant (His)

产品编号 TMPY-04144

规格	价格	库存	数量
50 μg	¥ 3,820	5日内发货
1 mg	¥ 29,100	5日内发货

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产品信息

生物活性	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q96MU8-2
别名	KRM1,kringle containing transmembrane protein 1,KREMEN
蛋白构建	A DNA sequence encoding the human KREMEN1 (NP_114434.3) (Met1-Thr394) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 20
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	42.6 kDa (predicted); 56.3 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. KREMEN1 is also essential for infection by a phylogenetic and pathogenic related group of Human type A Enteroviruses (EV-As). Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type, and Hand, Foot, And Mouth Disease.

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关键词

KRM-1 KRM 1