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AKT3 Protein, Human, Recombinant (GST)

产品编号 TMPY-04553

别名: PRKBG, RAC-γ, RAC-PK-γ, MPPH, PKB-γ, PKBG, RAC-PK-gamma, STK-2, PKB-GAMMA, RAC-gamma, v-akt murine thymoma viral oncogene homolog 3, MPPH2

AKT3 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 81 kDa and the accession number is Q9Y243-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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AKT3 Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,170		5日内发货

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参考文献

生物活性	No Kinase Activity
产品描述	AKT3 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 81 kDa and the accession number is Q9Y243-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	N-GST
蛋白编号	Q9Y243-1
别名	PRKBG, RAC-γ, RAC-PK-γ, MPPH, PKB-γ, PKBG, RAC-PK-gamma, STK-2, PKB-GAMMA, RAC-gamma, v-akt murine thymoma viral oncogene homolog 3, MPPH2
蛋白构建	The full length of Human PKBG (NP_005456.1) (Met 1-Glu 479)
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	81 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as unique functions within cells. The Akt signaling cascade initiates at the cell surface when growth factors or other extracellular stimuli activate phosphoinositide 3-kinase (PI3K). AKT3 was discovered to be the predominant isoform activated in sporadic melanomas. Levels of activity increased during melanoma progression with metastatic melanomas having the highest activity. Although mechanisms of AKT3 activation remain to be fully characterized, overexpression of AKT3 and decreased PTEN activity play important roles in this process. Targeted reduction of AKT3 activity decreased survival of melanoma tumor cells leading to inhibition of tumor development, which may be therapeutically effective for shrinking tumors in melanoma patients. AKT2 and AKT3 play an important role in the viability of human malignant glioma cells. Targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas.

参考文献

1. Mure H,et al.(2010) Akt2 and Akt3 play a pivotal role in malignant gliomas. Neuro Oncol. 12(3): 221-32.Koseoglu S,et al.(2007) AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biol Ther. 6(5): 755-62. 2. Cristiano BE,et al.(2006) A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition. Cancer Res. 66(24): 11718-25. 3. Robertson GP. (2005) Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev. 24(2): 273-85. 4. Altomare DA,et al.(2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene. 24: 7455-64.Stahl JM,et al.(2004) Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res. 64: 7002-10.

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Keywords

AKT3 Protein, Human, Recombinant (GST) MPPH 2 PRKBG RAC-γ RAC-PK-γ MPPH STK 2 PKB-γ PKBG STK2 RAC-PK-gamma MPPH-2 STK-2 PKB-GAMMA RAC-gamma v-akt murine thymoma viral oncogene homolog 3 MPPH2 recombinant recombinant-proteins proteins protein

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