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DOPA Decarboxylase/DDC Protein, Human, Recombinant (His)

产品编号 TMPY-01060

别名: dopa decarboxylase (aromatic L-amino acid decarboxylase), AADC

DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q53Y41.

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DOPA Decarboxylase/DDC Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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生物活性	Measured by its ability to convert the substrate 3, 4-dihydroxy L-phenylalanine (L-Dopa) to 3, 4-dihydroxyphenylethylamine (dopamine). The dopamine product is measured by its absorbance at 340 nm after derivatization with trinitrobenzene sulfonic acid. The specific activity is >1000 pmoles/min/μg.
产品描述	DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55 kDa and the accession number is Q53Y41.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	Q53Y41
别名	dopa decarboxylase (aromatic L-amino acid decarboxylase), AADC
蛋白构建	The full length of Human DDC (NP_000781.1) (Met 1-Glu 480) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 90 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.
分子量	55 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8, 10% glycerol.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.

参考文献

1. Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030. 2. Lisa, J. S. et al., 1992, Genomics 13: 469-471. 3. Moore, P. S. et al.,1996, Biochem. J. 315:249-256. 4. Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47. 5. Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823. 6. Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.

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Keywords

DOPA Decarboxylase/DDC Protein, Human, Recombinant (His) dopa decarboxylase (aromatic L-amino acid decarboxylase) aromatic L-amino acid decarboxylase dopa decarboxylase AADC recombinant recombinant-proteins proteins protein

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