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Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 2,840 | 期货 | |
10 mg | ¥ 4,285 | 期货 | |
50 mg | ¥ 12,785 | 期货 | |
100 mg | ¥ 17,885 | 期货 | |
200 mg | 询价 | 期货 | |
500 mg | 询价 | 期货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,480 | 期货 |
产品描述 | Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent HBV inhibitor (IC50: 53 nM). |
靶点活性 | HBV:53 nM |
体外活性 | BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers [2]. In HepG2.2.15 cells, BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level (IC50s: 32.6 and 132 nM). HBV DNA and HBcAg are inhibited in a dose-dependent manner [3]. |
体内活性 | BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces the hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30%, and dose-proportional plasma concentrations, about 60% in rats and dogs [1]. BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid [2]. |
分子量 | 395.76 |
分子式 | C18H13ClF3N3O2 |
CAS No. | 476617-51-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 37 mg/mL (93.49 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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