AV-153

Name: AV-153
Brand: TargetMol
SKU: T40345
Rating: 4.5 (1 reviews)

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产品编号 T40345Cas号 27296-05-5

AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.

AV-153

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产品编号 T40345Cas号 27296-05-5

规格	价格	库存	数量
25 mg	¥ 10,600	期货

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产品介绍

生物活性

产品描述	AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
体外活性	AV-153 causes IC 50 s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively[1]. AV-153 (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13-67%[1].