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DPH 是一种有效的细胞渗透的 c-Abl 激活剂。DPH 在刺激 c-Abl 活化方面显示出强大的酶活性和细胞活性。
DPH 是一种有效的细胞渗透的 c-Abl 激活剂。DPH 在刺激 c-Abl 活化方面显示出强大的酶活性和细胞活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 233 | 现货 | |
5 mg | ¥ 538 | 现货 | |
10 mg | ¥ 859 | 现货 | |
25 mg | ¥ 1,860 | 现货 | |
50 mg | ¥ 2,980 | 现货 | |
100 mg | ¥ 4,290 | 现货 | |
200 mg | ¥ 5,970 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 589 | 现货 |
产品描述 | DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation. |
体外活性 | DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation. DPH binds to the myristoyl binding site. It also prevents the formation of the bent conformation of the αI helix through steric hindrance. Which is a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site [1]. |
分子量 | 336.32 |
分子式 | C18H13FN4O2 |
CAS No. | 484049-04-9 |
Smiles | Fc1ccc(cc1)-c1nn(cc1C1NC(=O)NC1=O)-c1ccccc1 |
密度 | 1.45 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 90 mg/mL (267.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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