JH295

Name: JH295
Brand: TargetMol
SKU: T38710
Price: 223 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T38710Cas号 1311143-71-1

JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.

JH295

还可以

产品编号 T38710Cas号 1311143-71-1

规格	价格	库存
5 mg	¥ 3,730	6-8周
25 mg	¥ 15,000	6-8周
50 mg	¥ 19,500	6-8周
100 mg	¥ 28,300	6-8周

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产品介绍

生物活性

产品描述	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
靶点活性	NEK2:770 nM (IC50)
体外活性	JH295 (Compound 16; 0.08-20 μM; 45 minutes; RPMI7951 cells) treatment inhibits WT Nek2 in cells with an IC 50 of ~1.3 μM, whereas it has little effect on the C22V mutant[1]. Western Blot Analysis[1]Cell Line: RPMI7951 cells Concentration: 0.08 μM, 0.25 μM, 0.74 μM, 2.2 μM, 6.6 μM, 20 μM Incubation Time: 45 minutes Result: Inhibited WT Nek2 in cells with an IC50 of ~1.3 μM, whereas had little effect on the C22V mutant.