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BM635
还可以产品编号 T10563Cas号 1493762-74-5
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
BM635
还可以产品编号 T10563Cas号 1493762-74-5
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 2,970 | 6-8周 | |
| 25 mg | ¥ 10,500 | 6-8周 | |
| 50 mg | ¥ 13,700 | 6-8周 | |
| 100 mg | ¥ 17,500 | 6-8周 |
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产品介绍
生物活性
化学信息
| 产品描述 | BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). |
| 靶点活性 | M. tuberculosis (strain H37Rv):（MIC50） 0.12 μM |
| 体内活性 | BM635 has potent MIC (0.12 μM), Tox50:MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity (ED99: 49 mg/Kg; IC95%: 43–54 mg/Kg) [1]. The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (Cmax: 1.62 μM) and a moderate bioavailability (46%) [2]. |
| 分子量 | 392.51 |
| 分子式 | C25H29FN2O |
| CAS No. | 1493762-74-5 |
| 密度 | 1.12 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 31 mg/mL (78.98 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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