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Sutetinib maleate为Sutetinib的马来酸盐形态,具备口服活性,能有效抑制多种与肿瘤生长及血管新生密切相关的酪氨酸激酶.这些酪氨酸激酶包括VEGFR(VEGFR-1/2/3的Ki=0.009 µM)、PDGFR(PDGFR-α/β的Ki=0.008 µM)以及原癌基因cKIT.Sutetinib maleate可以抑制内皮细胞和成纤维细胞的增殖、迁移与管状结构的形成,且在多种肿瘤细胞系中显示出明显的抗肿瘤效果.
Sutetinib maleate为Sutetinib的马来酸盐形态,具备口服活性,能有效抑制多种与肿瘤生长及血管新生密切相关的酪氨酸激酶.这些酪氨酸激酶包括VEGFR(VEGFR-1/2/3的Ki=0.009 µM)、PDGFR(PDGFR-α/β的Ki=0.008 µM)以及原癌基因cKIT.Sutetinib maleate可以抑制内皮细胞和成纤维细胞的增殖、迁移与管状结构的形成,且在多种肿瘤细胞系中显示出明显的抗肿瘤效果.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Sutetinib maleate is the maleate salt form of Sutetinib. This compound functions as an orally effective tyrosine kinase (tyrosine kinase) inhibitor that targets tyrosine kinases associated with tumor growth and angiogenesis, including VEGFR (VEGFR-1/2/3 with Ki=0.009 µM), PDGFR (PDGFR-α/β with Ki=0.008 µM), and the proto-oncogene cKIT. Sutetinib maleate inhibits the proliferation, migration, and tubular structure formation of endothelial and fibroblast cells, displaying antitumor activity across various tumor cell lines. |
分子量 | 555.58 |
分子式 | C30H29N5O6 |
CAS No. | 1701408-75-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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