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Sigma-1 receptor antagonist 1 是一种有效、特异性的 sigma-1 受体拮抗剂。 Sigma-1 receptor antagonist 1 具有抗神经性疼痛活性,可用于治疗神经性疼痛研究。
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Sigma-1 receptor antagonist 1 是一种有效、特异性的 sigma-1 受体拮抗剂。 Sigma-1 receptor antagonist 1 具有抗神经性疼痛活性,可用于治疗神经性疼痛研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 562 | 现货 | |
5 mg | ¥ 1,490 | 现货 | |
10 mg | ¥ 2,390 | 现货 | |
25 mg | ¥ 3,830 | 现货 | |
50 mg | ¥ 5,250 | 现货 | |
100 mg | ¥ 6,870 | 现货 | |
200 mg | ¥ 9,490 | 现货 |
产品描述 | Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies. |
靶点活性 | σ1 receptor:1.06 nM(Ki) |
体外活性 | Sigma‑1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold)[1]. |
体内活性 | In mice formalin model and rats CCI models of neuropathic pain, Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects[1]. |
分子量 | 380.31 |
分子式 | C19H23Cl2N3O |
CAS No. | 1639220-19-1 |
Smiles | Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(Cl)cc1 |
密度 | 1.219 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: <1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
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