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TIC10g,作为TLR7和TLR9(Toll样受体7和9)的双重抑制剂,能够在小鼠巨噬细胞(IC50为14.5 μM和6.5 μM)及人类B淋巴细胞(IC50为7.69 μM和11.5 μM)中抑制由TLR7和TLR9介导的TNF-α释放。此外,TIC10g还能抑制NF-κB与MAPK的活化,显示出对系统性红斑狼疮和类风湿性关节炎的抗炎活性。
TIC10g,作为TLR7和TLR9(Toll样受体7和9)的双重抑制剂,能够在小鼠巨噬细胞(IC50为14.5 μM和6.5 μM)及人类B淋巴细胞(IC50为7.69 μM和11.5 μM)中抑制由TLR7和TLR9介导的TNF-α释放。此外,TIC10g还能抑制NF-κB与MAPK的活化,显示出对系统性红斑狼疮和类风湿性关节炎的抗炎活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | TIC10g is a dual inhibitor of Toll-like receptors 7 and 9 (TLR7 and TLR9), effectively suppressing the release of TNF-α mediated by TLR7 and TLR9 in mouse macrophages (with IC50 values of 14.5 μM and 6.5 μM, respectively) and in human B lymphocytes (with IC50 values of 7.69 μM and 11.5 μM, respectively). TIC10g inhibits the activation of NF-κB and MAPK, exhibiting anti-inflammatory activity useful in treating conditions such as systemic lupus erythematosus and rheumatoid arthritis. |
分子量 | 367.4 |
分子式 | C20H21N3O4 |
CAS No. | 754998-88-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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